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Polyphenols have emerged as potential natural interventions for depression, influencing brain function through multiple pathways

In line with previous results obtained in rodent neuronal cultures 43 , we found that the administration of lactate in a concentration range of 520 mM (which are relatively high as compared to physiological ones 19 ) caused an immediate drop in the electrophysiological activity of hiPSCs-derived neuronal networks, in a concentration-dependent manner

Microglia also help remove brain toxins and cellular metabolic waste to maintain the homeostasis of the brain (Shukla and Sharma, 2011) can induce protection against A damage

The establishment of the day-night rhythm for melatonin secretion from the pineal gland typically takes two to three months post-birth, which may result in newborns lacking sufficient melatonin during the early postnatal period